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Table 12.14 Effects of Desipramine on Depression

Author

Year

Country

Research Design

PEDro

Sample Size

Methods
Outcomes

Wroblewski et al.

(1996)

USA

RCT

PEDro=4

N=10

Population: TBI; Mean Age=32.2 yr; Gender: Male=7, Female=3; Mean Time Post Injury=1.5 yr; Severity of Injury=Severe.

Treatment: The treatment group (n=6) received desipramine (150 mg/day for 30 days, 150-300 mg/day after) and the control group (n=4) received a placebo. The control group crossed over and received desipramine after day 30.

Outcome Measure: Diagnostic and Statistical Manual of Mental Disorders checklist and Affect/Mood Scale.

1.        3 individuals from each group had nearly complete resolution of depression on desipramine.

2.        70% of subjects showed improvement over time on the affect/mood scale (p=0.001).

3.        There were different rates of improvement over time in those started on the desipramine rather than placebo; with the treatment group making more rapid and greater improvements.

PEDro=Physiotherapy Evidence Database rating scale score (Moseley et al., 2002).