Table 12.14 Effects of Desipramine on Depression
Author Year Country Research Design PEDro Sample Size |
Methods |
Outcomes |
(1996) USA RCT PEDro=4 N=10 |
Population: TBI; Mean Age=32.2 yr; Gender: Male=7, Female=3; Mean Time Post Injury=1.5 yr; Severity of Injury=Severe. Treatment: The treatment group (n=6) received desipramine (150 mg/day for 30 days, 150-300 mg/day after) and the control group (n=4) received a placebo. The control group crossed over and received desipramine after day 30. Outcome Measure: Diagnostic and Statistical Manual of Mental Disorders checklist and Affect/Mood Scale. |
1. 3 individuals from each group had nearly complete resolution of depression on desipramine. 2. 70% of subjects showed improvement over time on the affect/mood scale (p=0.001). 3. There were different rates of improvement over time in those started on the desipramine rather than placebo; with the treatment group making more rapid and greater improvements. |