Table 12.27 Prophylactic Intervention of Heterotopic Ossification with EHDP
|
Author Year Country Study Design Sample Size |
Methods |
Outcomes |
|
Spielman et al. (1983) USA Cohort N=20 |
Population: Head Injury; Gender: Male=16; Female=4. Intervention Group (n=10): Mean Age=31 yr; Mean GCS=5.2. Control Group (n=10): Mean Age=27 yr; Mean GCS=5.5. Intervention: The prospective intervention group received EHDP (20 mg/kg/day for 12 wk, 10 mg/kg/day for next 12 wk) within 2-7 days post injury which continued for 6mo. The control group was retrospective and did not receive EHDP. Outcome Measure: Presence of fractures, development of HO. | 1. The EHDP treated group showed a significantly lower incidence of HO compared with controls (2 versus 7 patients, p<0.025). 2. Of the 9 that developed HO, 25 sites were affected; elbows (35%), shoulders (29%), hips (18%) and knees (18%) were most common. 7 individuals had restricted limb motion and 2 had ankylosis. |