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Table 12.43 Effects of Methylphenidate on Sleep Disorders

Author

Year

Country

Study Design

Sample Size

Methods Outcomes

Al-Adawi et al.

(2009)

Oman

PCT

N=30

Population: TBI; Mean Age=51 yr; Gender: Male=23, Female=7.

Treatment: The treatment group (n=17) received methylphenidate (5-10 mg at 8am and 2pm). The control group (n=13) received no medication.

Outcome Measure: Sleep State, Functional Independence Measure (FIM), Rancho Los Amigo Levels (RLAS) of Cognitive Functioning.

1.        The mean hours of sleep during a 24 hr period did not significantly differ between the treatment and control group (8.3 versus 9.0 hr, p=0.096).

2.        Mean hours of sleep at night for the treatment and control groups were 6.4 and 6.9 hr, respectively.

3.        Mean total FIM score was lower for those in the methylphenidate group than for the control group (30.0 versus 34.9, p=0.4).

4.        The scores on the RLAS were comparable between groups (p=0.479).