Metzger et al. (2018)

USA

Pre-Post test

N=5

Population: TBI=2, SAH=1, ICH=1, Undisclosed=1; Mean Age=43 yr; Gender: Male=3, Female=2; Mean Time Post Injury to intervention=5.6 d.

Intervention: Non-invasive active Intrathoracic Pressure regulation (aIPR) was used for 120 min to provide negative intrathoracic pressure regulation. Measurements were taken every 5 min starting 30 min before machine activation, and concluding 30 min after the completion of the intervention.

Outcome Measures: Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Mean Arterial Pressure (MAP).

1.        Three patients required Mannitol treatment prior to intervention.

2.        On average, ICP was significantly lower in all 5 patients during, and 30min after treatment compared to before (21% change, p=0.005).

3.        On average, CPP was significantly increased in all 5 patients during, and 30min after treatment compared to before (16% change, p=0.04)

4.        There was no change in MAP.