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Table 16.45 Multimodal Amantadine for Recovery of Consciousness Post ABI

 
Author/Year/ Country/ Study Design/N Methods Outcomes
Saniova et al. (2004) Slovakia Case Control N=74 Population: TBI; Amantadine Group (n=41): Mean Age=42.12 yr; Gender: Male=35, Female=6; Mean GCS=4.74. Control Group (n=33): Mean Age=43.91 yr; Gender: Male=30, Female=3; Mean GCS=4.70. Intervention: Patients were compared based on whether they had received standard therapy and amantadine (200 mg, 2×/ day) or standard therapy alone (control). Outcome Measure: Glasgow Coma Scale (GCS), Mortality.
  1. At discharge, patients treated with amantadine showed significantly higher GCS scores (9.76 versus 5.73, p<0.0001)
  2. At discharge, patients treated with amantadine had a significantly lower mortality rate (6.06% versus 51.51%, p<0.001) than controls.