Saniova et al.
(2004)
Slovakia
Case Control
N=74 |
Population: TBI; Amantadine Group (n=41): Mean Age=42.12 yr; Gender: Male=35, Female=6; Mean GCS=4.74. Control Group (n=33): Mean Age=43.91 yr; Gender: Male=30, Female=3; Mean GCS=4.70.
Intervention: Patients were compared based on whether they had received standard therapy and amantadine (200 mg, 2×/ day) or standard therapy alone (control).
Outcome Measure: Glasgow Coma Scale (GCS), Mortality. |
- At discharge, patients treated with amantadine showed significantly higher GCS scores (9.76 versus 5.73, p<0.0001)
- At discharge, patients treated with amantadine had a significantly lower mortality rate (6.06% versus 51.51%, p<0.001) than controls.
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