Hayashi et al.
(2005)
Japan
PCT
N=41 |
Population: TBI; Treatment Group (TG, n=20): Mean Age=28.9 yr; Mean GCS=5. Control Group (CG, n=21): Mean Age=33.6 yr; Mean GCS=4.7.
Intervention: Participants received either hypothermia (32-36°C, TG) or normothermia (CG). Hypothermia was delivered for 72-84 hr via cooling blankets and nasogastric lavage with iced saline. Outcomes were assessed before and after treatment, and at 6 mo follow-up.
Outcome Measure: Glasgow Outcome Scale (GOS). |
- The TG had a higher rate of favourable outcome (GOS=4-5) than the CG (55% versus 25%).
- The TG had lower rates of unfavourable outcome (GOS=2-3; 10% versus 20%) and death (35% versus 60%) than the CG.
- Within the TG, those who received very mild hypothermia (35-36°C, n=10) had a higher rate of favourable outcome (80% versus 30%) than those who received mild hypothermia (32-34°C, n=10).
- Those who received very mild hypothermia had a lower rate of complications than those who received mild hypothermia (30% versus 0%).
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