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Table 16.46 Miscellaneous Outcomes – Hypothermia for Acute Management Post ABI

 
Author/Year/ Country/ Study Design/N Methods Outcomes
Hayashi et al. (2005) Japan PCT N=41 Population:  TBI; Treatment Group (TG, n=20): Mean Age=28.9 yr; Mean GCS=5. Control Group (CG, n=21): Mean Age=33.6 yr; Mean GCS=4.7. Intervention: Participants received either hypothermia (32-36°C, TG) or normothermia (CG). Hypothermia was delivered for 72-84 hr via cooling blankets and nasogastric lavage with iced saline. Outcomes were assessed before and after treatment, and at 6 mo follow-up. Outcome Measure: Glasgow Outcome Scale (GOS).
  1. The TG had a higher rate of favourable outcome (GOS=4-5) than the CG (55% versus 25%).
  2. The TG had lower rates of unfavourable outcome (GOS=2-3; 10% versus 20%) and death (35% versus 60%) than the CG.
  3. Within the TG, those who received very mild hypothermia (35-36°C, n=10) had a higher rate of favourable outcome (80% versus 30%) than those who received mild hypothermia (32-34°C, n=10).
  4. Those who received very mild hypothermia had a lower rate of complications than those who received mild hypothermia (30% versus 0%).
Chen et al. (2001) China PCT N=30 Population: ABI. Intervention: Participants received hypothermia (33-35°C, treatment) for 10 hr/day over 3-10 days or conventional treatment (control). Outcome Measure: Mortality.
  1. Mortality was significantly lower in the treatment than control group.