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Table 16.52 Miscellaneous Outcomes – Pentobarbital for Acute Management Post ABI

 
Author/Year/ Country/ Study Design/N Methods Outcomes
Fried et al. (1989) USA PCT N=7 Population: TBI; Mean Age=31 yr; Gender: Male=4, Female=3; Time Post Injury≤1 wk; Mean GCS=4.7. Intervention: Patients unresponsive to conventional therapy received pentobarbital administered as a bolus followed by a continuous infusion to achieve serum concentrations of 20-40m g/L (n=4). Patients responsive to conventional therapy formed the control group (n=7). Outcome Measure: Energy Expenditure, Urinary Nitrogen Excretion, Nitrogen Balance, Urinary 3-Methylhistidine Excretion.
  1. Patients treated with pentobarbital had significantly lower energy expenditure (p<0.01), lower urinary total nitrogen excretion (p<0.01), and improved nitrogen balance (p<0.05) than the control group.
  2. There was no significant difference in urinary 3-methylhistidine excretion between groups.