Fried et al.
(1989)
USA
PCT
N=7 |
Population: TBI; Mean Age=31 yr; Gender: Male=4, Female=3; Time Post Injury≤1 wk; Mean GCS=4.7.
Intervention: Patients unresponsive to conventional therapy received pentobarbital administered as a bolus followed by a continuous infusion to achieve serum concentrations of 20-40m g/L (n=4). Patients responsive to conventional therapy formed the control group (n=7).
Outcome Measure: Energy Expenditure, Urinary Nitrogen Excretion, Nitrogen Balance, Urinary 3-Methylhistidine Excretion. |
- Patients treated with pentobarbital had significantly lower energy expenditure (p<0.01), lower urinary total nitrogen excretion (p<0.01), and improved nitrogen balance (p<0.05) than the control group.
- There was no significant difference in urinary 3-methylhistidine excretion between groups.
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