Alvarez et al.

(2003)

Spain

Pre-Post

N=20

Population: TBI; Mean Age=30.1yr; Gender: Male=15, Female=5; Mean GCS=6.1; Time Post Injury Range=23-1107d.

Intervention: Patients with TBI received a total of 20 intravenous infusions of cerebrolysin solution (30mL/infusion) over 4wk. Assessments were made at baseline, during treatment, and after the 4wk treatment period.

Outcome Measure: Syndrome Kurztest test (SKT), electroencephalogram (EEG)/brain mapping recordings, and Glasgow Outcome Scale (GOS).

1.        Compared to baseline, patients with TBI showed a significant decrease in slow bioelectrical activity frequencies (delta: p<0.01; theta: p<0.05), and a significant increase in fast frequencies (beta: p<0.01) after receiving cerebrolysin, suggesting improvement in brain bioelectrical activity.

2.        Significant improvements in SKT performance was noted from pre to post treatment (15.9±2.4 versus 12.0±2.1; p<0.01).

3.        GOS scores significantly improved from pre to post treatment (3.7±0.3 versus 3.95±0.3; p<0.05).