Author

Year

Country

Research Design

PEDro

Sample Size

Hart et al.

(2018)

United States

RCT

PEDro=10

N=32

Population: DEX Group (N=17): Mean age=39.6yr; Gender: Male=11, Female=6; Mean GCS=8.2; Mean time post-injury=53.6dy. Control Group (N=15): Mean age=38.7yr; Gender: Male=15, Female=0; Mean GCS=7.5; Mean time post-injury=60.2dy.

Intervention: Participants either received the placebo or 10 mg of dextroamphetamine (DEX). Each treatment was administered once a day, in the morning, for 3 weeks.

Outcomes: Moss Attention Rating Scale (MARS), Hopkins Rehabilitation Engagement Rating Scale (HRER), Cognitive Failures Questionnaire (CFQ), Rating Scale of Attentional Behavior (RSAB), Finger Taping Test (FT), the Symbol Digit Modalities Test (SDMT), Disability Rating Scale (DRS), Agitated Behavior Scale (ABS), Profile of Mood States (POMS),

1.        There was a significant difference between groups on the ABS (p=0.04), with the DEX group demonstrating more agitation over time.

2.        No other significant differences were found.