Table 8.14 Effects of Methylphenidate on Agitation and Attention Post ABI

Author Year Country Research Design PEDro Sample Size	Methods	Outcome
Mooney & Haas (1993) USA RCT PEDro=5 N=38	Population: TBI; Mean Age=29.45yr; Gender: Male=38, Female=0; Mean Time Post Injury=27.08mo. Intervention: Patients received methylphenidate (30 mg/day; n=19) or placebo (n=19) for 6 wk. Outcome Measure: State-Trait Anger Scale, Katz Adjustment Scale – Belligerence, Profile of Mood States – Anger-Hostility.	1. After controlling for differences in baseline anger scores, there was a significant main effect for the drug treatment (p<0.001). 2. For all of the anger outcome measures, a significant drug by time interaction effect was noted (p=0.002).

Author

Year

Country

Research Design

PEDro

Sample Size

Methods

Outcome

Mooney & Haas

(1993)

USA

RCT

PEDro=5

N=38

Population: TBI; Mean Age=29.45yr; Gender: Male=38, Female=0; Mean Time Post Injury=27.08mo.

Intervention: Patients received methylphenidate (30 mg/day; n=19) or placebo (n=19) for 6 wk.

Outcome Measure: State-Trait Anger Scale, Katz Adjustment Scale – Belligerence, Profile of Mood States – Anger-Hostility.

1. After controlling for differences in baseline anger scores, there was a significant main effect for the drug treatment (p<0.001).

2. For all of the anger outcome measures, a significant drug by time interaction effect was noted (p=0.002).

PEDro=Physiotherapy Evidence Database rating scale (Moseley et al. 2002)