Azouvi et al.

(1999)

France

Pre-Post

N=10

Population: TBI; Mean Age=33.7yr; Gender: Male=8, Female=2; Mean GCS Score=5.3; Mean Time Post Injury=58 wk.

Intervention: Patients received carbamazepine (mean dose=9.47±2.9 mg/kg/day) for 8 wk.

Outcome Measure: Neurobehavioural Rating Scale (NRS), Agitated Behaviour Scale (ABS), Katz Adjustment Scale (KAS), Mini-Mental Status Examination (MMSE).

1.         Total NRS-R and ABS scores showed significant improvement (p=0.02); improvements plateaued after 2 wk.

2.         At follow-up, significant improvements were shown for only the irritability (p<0.01) and disinhibition (p<0.05) portions of NRS-R.

3.         Global NRS-R significantly decreased from baseline (p=0.01).

4.         No significant changes on MMSE were observed (p>0.01).