Author

Year

Country

Research Design

PEDro

Sample Size

Methods

Outcome

Kim & Bijlani

(2006)

USA

Case Series

N=7

Population: TBI; Mean Age=48.9 yr; Gender: Male=4, Female=3; Mean Time Post Injury=23.1 mo.

Intervention: Patients received quetiapine (25-300 mg/day; mean=110.7 mg/day) for 6 wk.

Outcome Measure: Overt Aggression Scale-Modified (OAS-M), Clinical Global Impression (CGI), Neurobehavioural Functioning Inventory (NFI), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

1.         After treatment, OAS scores were significantly reduced (p=0.002).

2.         After treatment, CGI scores were significantly improved (p=0.002).

3.         After treatment, significant improvements were noted on the aggression subscale of NFI (p=0.036).

4.         RBANS scores indicated a mean improvement of 8.02% (p=0.027).