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Table 8.21 Effects of Methotrimeprazine on Agitation and Aggression Post ABI

Author

Year

Country

Research Design

PEDro

Sample Size

Methods Outcomes

Maryniak et al.

(2001)

Canada

Case Series

N=120

Population: TBI=95, ABI=25; Mean Age=37.8yr; Gender: Male=89, Female=31.

Intervention: Retrospective review of patients attending an inpatient ABI rehabilitation unit, and some received methotrimeprazine (MTZ).

Outcome Measure: Agitated Behaviour Scale.

1.         Fifty-eight percent had agitation but 56 patients were treated with MTZ (10-25 mg, 4x/day) with a mean length of treatment of 41.9 days.

2.         MTZ, was both safe and effective for controlling agitation in 96% of patients.