Table 8.24 Effects of Propranolol on Agitation and Aggression Post ABI
Author Year Country Research Design PEDro Sample Size |
Methods | Outcome |
(1992) USA RCT PEDro=7 N=21 |
Population: TBI; Severity of Injury: GCS <8. Intervention: Patients were randomized to receive either propranolol (n=11; 60 mg/day, max 420mg) or placebo (n=10). Outcome Measure: Overt Aggression Scale. |
1. No significant differences between the two treatments in terms of agitation episodes per wk. 2. More intense episodes of agitation with placebo than propranolol (p<0.05). 3. More participants were placed in restraints with placebo than propranolol (p<0.05). 4. No differences between the two treatments in the proportion receiving sedating drugs or drugs for agitation. |
(1986) USA RCT PEDro=7 N=10 |
Population: Mean Age=52yr; Gender: Male=9, Female=0; Mean Time Post Injury=7.8yr. Intervention: Patients were randomized to receive either propranolol (520 mg/day) or placebo for 11wk. Groups were then crossed over and received the alternate treatment for 11wk. Outcome Measure: Assaultive behaviour, Supplemental medication, Nurses Observation Scale for Inpatient Evaluation. |
1. Significantly fewer assaults and attempted assaults occurred during propranolol treatment when compared to placebo (p<0.05). 2. No significant changes in irritability, social interests, or psychomotor retardation were noted. 3. No abnormalities were noted on laboratory measures. |