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Table 7.3 Light Therapy for the Management of Fatigue Post ABI

Author Year

Country

Study Design

Sample Size

Methods Outcome

Quera Salva et al.,

(2020)

France

RCT

PEDro=7

NInitial=20, NFinal=20

Population: TBI=20; Intervention Group (Blue-enriched white light therapy, BWL; n=10): Mean Age=34.20±10.73yr; Sex Ratio=2.33; Mean Time Post Injury=7.93±9.99yr; Severity: Mean GCS=5.88±1.55. Control Group (No light therapy, N-BWL; n=10): Mean Age=39±9.81yr; Sex Ratio=1.22; Mean Time Post Injury=10.02±10.71yr; Severity: Mean GCS=6±1.83. Intervention: Participants were randomly allocated to receive light therapy (blue-enriched white light, 30min upon waking for 4wk) or no light therapy. Outcome measures were assessed at baseline, 2wk, 4wk and 6wk. Outcome Measures: Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Hamilton Depression Scale (HDS-17), Short Form Health Survey (SF-12). 1.        BWL significantly improved fatigue severity (FSS, p=.026) from baseline to 4wk. (p<.001); however, improvements disappeared at 6wk, 2wk following treatment cessation. 2.        BWL significantly improved measures of depression from baseline to 4wk (HADS17, p=.04). Improvements were maintained at 6wk. 3.        No significant differences in quality of life (SF-12, p>.05), sleep quality (PSQI, p>.05), or daytime sleepiness (ESS, p>.05) were observed between groups.  

Sinclair et al.

(2014)

Australia

RCT

PEDro=6

N=30

Population: TBI=30; Mean Age= 42yr; Male=24, Female=6; Mean Time Post Injury=1106d; Severity: Mild=7, Moderate=8, Severe=15.

Intervention: Participants were randomized to one of three home-based treatment groups: blue light therapy (n=10), yellow light therapy (n=10) or the no treatment control group (n=10). Participants were instructed to use the device for 45min each morning, within 2hr of waking up, for 4wk. Assessments were conducted at baseline, 4wk and 8wk.

Outcome Measure: Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI).

1.        Compared to the control group, the blue light therapy group showed a significantly greater reduction in fatigue (FSS; p<0.001) and a significant reduction in daytime sleepiness (ESS; p<0.01). However, no significant improvements were observed in the yellow light therapy group when compared to controls.

2.        There was no significant change in PSQI score in any treatment condition (p>0.05).