Author Year

Country

Study Design

Sample Size

Zhang et al. (2010)

China

Pre-Post

N=68

Population: Craniocerebral Injury (CI); Mean Age=27.8yr; Gender: Male=51, Female=17; Time Post Injury ≤24hr; Injury Severity: Mild=17, Moderate=18, Severe=33.

Intervention: Patients hospitalized within 24hr of CI were assessed for post-injury hyponatremia, which was defined as blood [Na⁺] <135mmol/L. Those with hyponatremia received thyrotropin-releasing hormone (TRH) stimulation.

Outcome Measure: Incidence of hyponatremia, Level of ADH.

1.        TRH stimulation was shown to mitigate symptoms of hyponatremia caused by SIADH by reducing blood ADH concentration from baseline to 60min post TRH stimulation (130.87±4.32 to 72.64±3.11pg/mL; p<0.01).

2.        TRH stimulation was not effective in resolving hyponatremia caused by cerebral salt-wasting syndrome.