Glenn et al.

(1989)

USA

Case Series

N=10

Population: TBI=8, CVA=2; Mean Age=31.6yr; Gender: Male=5, Female=5.

Intervention: Patients showing mood disorders and unstable, aggressive, combative, or self-destructive behaviour were administered lithium.

Outcome Measure: Observed improvement.

1.         Five participants showed a significant improvement with no decrease in motor or cognitive performance, one showed moderate response, and one improved dramatically but regressed after 7wk.

2.         Four participants regressed after medications stopped.

3.         Three participants had neurotoxic side effects.