Chahine & Chemali (2006a)

Lebanon

Case Series

N=4

Population: TBI; Mean Age=26 yr; Gender: Male=4, Female=0.

Treatment: Lamotrigine (range: 125 to 300 mg/day) to reduce inappropriate behaviours (e.g. laughing, impulsivity or verbal aggression).

Outcome Measure: Frequency of crying, pathological laughing, behaviours of impulsivity, and seizures.

1.        All behaviours decreased once the individual was placed on lamotrigine.

2.        Crying decreased, and inappropriate laughing ceased.

3.        Impulsivity did not cease.