Table 12.8 Effects of Cerebrolysin on Cognitive Functioning
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Author Year Country Research Design PEDro Sample Size |
Methods | Outcomes |
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Alvarez et al. (2003) Spain Pre-Post N=20 |
Population: TBI; Mean Age=30.1 yr; Gender: Male=15, Female=5; Mean GCS=6.1; Time Post Injury Range=23-1107 d. Intervention: Patients with TBI received a total of 20 intravenous infusions of cerebrolysin solution (30 mL/infusion) over 4 wk. Assessments were made at baseline, during treatment, and after the 4 wk treatment period. Outcome Measures: Syndrome Kurztest (SKT), Electroencephalogram (EEG)/brain mapping recordings, Glasgow Outcome Scale (GOS). | 1. Compared to baseline, patients with TBI showed a significant decrease in slow bioelectrical activity frequencies (delta: p<0.010; theta: p<0.050), and a significant increase in fast frequencies (beta: p<0.010) after receiving cerebrolysin, suggesting improvement in brain bioelectrical activity. 2. Significant improvements in SKT performance was noted from pre to post treatment (15.9±2.4 versus 12.0±2.1; p<0.010). 3. GOS scores significantly improved from pre to post treatment (3.7±0.3 versus 3.95±0.3; p<0.050). |