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Table 16.44 Multimodal Electrical Stimulation for Recovery of Consciousness Post ABI

by | Dec 13, 2018

Table 16.44 Multimodal Electrical Stimulation for Recovery of Consciousness Post ABI

 

Author (Year)

Country

Study Design

PEDro Score

Sample Size

 Methods Outcome
Lei et al.

(2015)

China

Cohort

N=437

 Population: TBI; Treatment Group (TG, n=221): Mean Age=41.31 yr; Gender: Male=154, Female=67; Mean GCS=6.27. Control Group (CG, n=216): Mean Age=43.21 yr; Gender: Male=145, Female=71; Mean GCS=6.31.

Intervention: Participants in a minimally conscious state (MCS) or vegetative state (VERSUS) were assigned to receive right median electrical stimulation (RMNS, TG) or standard care (CG). RMNS was delivered for 8 hr/day over 2 wk (15-20 mA, 40 Hz, 20 sec/min). Outcomes were assessed before and after each treatment session, with follow-up at 6mo.

Outcome Measures: Glasgow Coma Scale (GCS), Functional Independence Measure (FIM).
  1. Over 2 wk, GCS increased in both groups. The increase was more rapid in the TG than the CG, but the difference was not significant (p=0.1472).
  2. At end of 2 wk, mean GCS was higher in the TG than the CG, but the difference was not significant (8.43 versus 7.47, p=0.0532).
  3. At 6 mo, significantly more of the TG regained consciousness than the CG (60% versus 46%, p=0.0073)
  4. At 6mo, significantly more of the CG remained in VERSUS than the TG (32% versus 18%, p=0.0012), but there was no significant difference in those remaining in MCS (22% versus 23%, p=0.8929).
  5. At 6 mo, mean FIM score was significantly in the TG than the CG (91.45 versus 76.23, p<0.0001).