| Lei et al.
(2015)
China
Cohort
N=437 |
Population: TBI; Treatment Group (TG, n=221): Mean Age=41.31 yr; Gender: Male=154, Female=67; Mean GCS=6.27. Control Group (CG, n=216): Mean Age=43.21 yr; Gender: Male=145, Female=71; Mean GCS=6.31.
Intervention: Participants in a minimally conscious state (MCS) or vegetative state (VERSUS) were assigned to receive right median electrical stimulation (RMNS, TG) or standard care (CG). RMNS was delivered for 8 hr/day over 2 wk (15-20 mA, 40 Hz, 20 sec/min). Outcomes were assessed before and after each treatment session, with follow-up at 6mo.
Outcome Measures: Glasgow Coma Scale (GCS), Functional Independence Measure (FIM). |
- Over 2 wk, GCS increased in both groups. The increase was more rapid in the TG than the CG, but the difference was not significant (p=0.1472).
- At end of 2 wk, mean GCS was higher in the TG than the CG, but the difference was not significant (8.43 versus 7.47, p=0.0532).
- At 6 mo, significantly more of the TG regained consciousness than the CG (60% versus 46%, p=0.0073)
- At 6mo, significantly more of the CG remained in VERSUS than the TG (32% versus 18%, p=0.0012), but there was no significant difference in those remaining in MCS (22% versus 23%, p=0.8929).
- At 6 mo, mean FIM score was significantly in the TG than the CG (91.45 versus 76.23, p<0.0001).
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