Select Page

Table 4.26 Antiepileptic Medications to Treat Pain Post TBI (Gould, 2007; Guay, 2003; Zasler et al., 2011)

Antiepileptic Medication Typical Dose; Dose Range Adverse Events (partial list)
Carbamazepine (Tegretol®) 200 mg q 8 hr; 100-1600 mg/day Drowsiness, bone marrow suppression, kidney stones
Valproic acid (Depekene®) 250 mg q 8 hr; 600-2400 mg/day Drowsiness, headache, sleepiness, agitation, mood swings, memory loss
Phenytoin (Dilantin®) 100 mg q 8 hr; 200-600 mg/day Double vision, imbalance, slurred speech
Gabapentine (Neurontin) 600 mg q 8hr; 200-3600 mg/day Drowsiness, dizziness
Clonazepam (Klonopin®) 0.5 mg q 8 hr; 2-7 mg/day Drowsiness, disequilibrium, abnormal behavior
Oxcarbazepine (Tripeptal®) 300-600 mg q 12 hr; 150-1800 mg/day Drowsiness, lightheadedness, dizziness
Lamotrigine (Lamictal®) 50-100 mg q 12hr; 50-200 mg/day Rash, fatigue, stomach upset
Topiramate 25 mg q 12 hr; 200-400 mg/day Ataxia, impaired concentration, confusion, dizziness, fatigue, speech disturbances, language problems.
Pregabalin (Lyrica®) 300-450 mg/day; 150-600 mg/day Drowsiness, dizziness
Levetiracetam (Keppra®) 250-500 mg q 12 hr; 250-1500 mg/day Drowsiness, dizziness