Author

Year

Country

Research Design

PEDro

Sample Size

Methods

Outcome

Hammond et al.

(2018)

United States

RCT

PEDro= 9

N=119

Population: Mean age=38.6yr; Mean time post-injury=6.2yr; Injury severity: GCS<13.

Intervention: Individuals were allocated to receive either the placebo or 100mg amantadine twice a day for 60 days. Assessments were completed at baseline, day 28, and day 60.

Outcomes: Digit-span from Wechsler Memory Scale-III (DS), Trail Making Test (TMT), Controlled Oral Word Association Test (COWAT), Learning/Memory Index (LMI), Attention/Processing Speed Index (APSI), overall composite (GCI).

1.        No significant differences were seen on the DS, TMT, COWAT, or the APSI between groups at any time point.

2.        The treatment group had significantly lower LMI scores at day 28 compared to the control group (p=0.001), this effect was not present at 60-day follow-up.

3.        The treatment group had significantly lower scores on the GCI compared to the control group at day 28 (p=0.002), this effect was not present at day 60 follow-up.