Khateb et al.

(2005)

Switzerland

Pre-Post

N_initial=15, N_final=10

Population: TBI; Mean age=43 yr; Gender: Male=8, Female=7; Mean Time Post Injury=4 2mo.

Intervention:  Patients were administered donepezil 5 mg/day for 1 mo, followed by 10 mg/day for 2 mos.

Outcome Measure: Stroop test, Trail Making Test (TMT), Rey Auditory Verbal Memory Test (RAVMT), Test for Attentional Performance (TAP).

1.        Four of 15 participants stopped due to side effects within the first week (e.g., nausea, sleep disorders, anxiety, dizziness, etc.).

2.        Changes on the neuropsychological evaluation show modest improvement. However, the comparison of the global score of all questionnaires before and after therapy was not significant (p=0.058).

3.        A significant improvement in executive function was only found for the Stroop Colour naming test (87.3±22.9 to 79.5±19.1, p=0.030); the RAVMT-learning for learning and memory (47.7±6.9 to 53.5±5.0, p=0.050); and the errors subsection of divided attention for attention, (5.8±3.3 to 2.9±2.7, p=0.030).