Table 6.38 The Effect of Bromocriptine on Executive and General Cognitive Functioning Post ABI
Author Year Country Research Design PEDro Sample Size |
Methods | Outcome |
(1998) USA RCT PEDro=4 N=24 |
Population: TBI; Median Age=32.5 yr; Gender: Male=20, Female=4; GCS Range=3-8; Time Post injury Range=27 d-300 mo. Intervention: In a crossover design, participants were randomly assigned to receive bromocriptine (2.5 mg) then placebo or receive treatment in the reverse order. Outcome Measure: Dual-task Paradigm (counting and digit span), Stroop Test, Spatial Delayed-response Task, Wisconsin Card Sorting Test (WCST), Reading Span Test, Trail Making Test (TMT), Controlled Oral Word Association Test (COWAT), and Control Tasks. |
1. Following bromocriptine treatment there were significant improvements on the dual-task counting (p=0.028), dual-task digit span (p=0.016), TMT (p=0.013), Stroop Test (p=0.050), COWAT (p=0.020), and WCST (p=0.041). 2. Bromocriptine had no significant effects on working memory (e.g. spatial delayed-response task and reading span test; p=0.978), or on control tasks (p=0.095). |
(1996) UK Case Series N=11 |
Population: TBI=8, SAH=3; Mean Age=36 yr; Gender: Male=6, Female=5; Time Post Injury Range=2mo-5 yr. Intervention: Patients received bromocriptine (a maximum dose of 5-10 mg/d). Patient assessments included two baseline evaluations (BL1 and BL2), evaluation when stabilized at maximum bromocriptine dose (MAXBROMO), and two post withdrawal evaluations (POST1 and POST2). Outcome Measure: Percentage Participation index (PPI), Spontaneity, Motivation, Card Arranging Reward Responsivity Objective Test (CARROT), Digit Span, Buschke Selective Reminding Test (BSRT), Verbal Fluency, Hospital Anxiety and Depression Scale. |
1. Reported PPI (p<0.0001), motivation, and spontaneity (both p<0.005) increased significantly from BL2 to MAXBROMO. Improvements were seen in CARROT as well (p<0.0001). 2. Significant improvements were observed from BL2 to MAXBROMO on the digit span (p<0.001), BSRT (p<0.01), and verbal fluency (p<0.001). Scores on all three tests decreased (non-significant) from MAXBROMO to POST1, scores recovered to near MAXBROMO levels by POST2. 3. Bromocriptine was not associated with improvements in mood state. |