Author

Year

Country

Research Design

PEDro

Sample Size

Methods

Results

Chahine & Chemali

(2006)

Lebanon

Case Series

N=4

Population: TBI; Mean Age=26 yr; Gender: Male=4, Female=0.

Intervention: Lamotrigine (range 125 to 300mg/d) to reduce inappropriate behaviours (e.g. laughing, impulsivity or verbal aggression).

Outcome Measure: Frequency of crying, pathological laughing, behaviours of impulsivity, and seizures. Also, notes of depression.

1.         All behaviours decreased once the patient was placed on lamotrigine.

2.         Crying decreased and inappropriate laughing ceased.

3.         Impulsivity did not cease.